In 2002, Gauthier and co-workers documented an approach through lithium zincates using only one third equivalent of zinc chloride for the synthesis of 5-aryl-2-furaldehydes from 5-lithio-2-furaldehyde diethyl acetal
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چکیده
Other studies avoided the use of a zinc salt by generating lithium zincates either by iodine-metal exchange 7 or by deprotonation. 8 In 2002, Gauthier and co-workers documented an approach through lithium zincates using only one third equivalent of zinc chloride for the synthesis of 5-aryl-2-furaldehydes from 5-lithio-2-furaldehyde diethyl acetal. 9 In addition, Mutule and Suma described in 2005 one pot Grignard formation-transmetalation-Negishi reactions using the less hygroscopic TMEDA-chelated zinc chloride. 10
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